The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is retained in RCC metastatic tissues. Moreover, proteom...

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Bibliographic Details
Main Authors: Hyeyoung Nam, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, Maria V. Liberti, Jason W. Locasale, Tanecia Mitchell, Sooryanarayana Varambally, Sunil Sudarshan
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-11-01
Series:JCI Insight
Subjects:
Cell biology
Online Access:https://doi.org/10.1172/jci.insight.148438

Internet

https://doi.org/10.1172/jci.insight.148438

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