Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects

Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects

Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the treatment of different types of cancers and the management of chronic inflammatory diseases. However, its use is associated with hepatotoxicity. Vitamin C (VC) and curcumin (CUR) exhibit anti-inflammatory and antiox...

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Bibliographic Details
Main Authors: Dhekra Hasan Khudhair, Ali I. Al-Gareeb, Hayder M. Al-kuraishy, Aya H. El-Kadem, Engy Elekhnawy, Walaa A. Negm, Sameh Saber, Simona Cavalu, Adrian Tirla, Saqer S. Alotaibi, Gaber El-Saber Batiha
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
liver
oxidative stress
antioxidants
vitamin C
curcumin
Methotrexate
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.866343/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.866343/full

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