Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

ABSTRACT The discovery of antimicrobials with novel mechanisms of action is crucial to tackle the foreseen global health crisis due to antimicrobial resistance. Bacterial two-component signaling systems (TCSs) are attractive targets for the discovery of novel antibacterial agents. TCS-encoding genes...

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Bibliographic Details
Main Authors: Blanca Fernandez-Ciruelos, Marco Albanese, Anmol Adhav, Vitalii Solomin, Arabela Ritchie-Martinez, Femke Taverne, Nadya Velikova, Aigars Jirgensons, Alberto Marina, Paul W. Finn, Jerry M. Wells
Format: Article
Language:English
Published: American Society for Microbiology 2024-08-01
Series:Microbiology Spectrum
Subjects:
antimicrobial
repurposing
Hsp90
two-component system
membrane disruption
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00146-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.00146-24

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