Systems Cancer Biology and the Controlling Mechanisms for the J-Shaped Cancer dose Response: Towards Relaxing the LNT Hypothesis

The hormesis phenomena or J-shaped dose response have been accepted as a common phenomenon regardless of the involved biological model, endpoint measured and chemical class/physical stressor. This paper first introduced a mathematical dose response model based on systems biology approach. It links m...

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Bibliographic Details
Main Authors: In Chio Lou, Yuchao Zhao, Yingjie Wu, Paolo F Ricci
Format: Article
Language:English
Published: SAGE Publishing 2013-07-01
Series:Dose-Response
Online Access:https://doi.org/10.2203/dose-response.12-037.Lou