The asymmetric Henry reaction as synthetic tool for the preparation of the drugs linezolid and rivaroxaban

The asymmetric Henry reaction as synthetic tool for the preparation of the drugs linezolid and rivaroxaban

The human drugs – the antibiotic linezolid (1) and the anticoagulant rivaroxaban (2) – belong among modern pharmaceutics, which contain an oxazolidine-2-one moiety bearing a stereogenic center. The chirality of these drugs is a fundamental attribute for their biological activity. Herein, one of the...

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Bibliographic Details
Main Authors: Martin Vrbický, Karel Macek, Jaroslav Pochobradský, Jan Svoboda, Miloš Sedlák, Pavel Drabina
Format: Article
Language:English
Published: Beilstein-Institut 2022-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
asymmetric henry reaction
enantioselective catalysis
linezolid
oxazolidine-2-one derivatives
rivaroxaban
Online Access:https://doi.org/10.3762/bjoc.18.46

Internet

https://doi.org/10.3762/bjoc.18.46

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