Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome

Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome

Melanoma differentiation-associated protein 5 (MDA5) is a crucial RIG-I-like receptor RNA helicase enzyme encoded by <i>IFIH1</i> in humans. Single nucleotide polymorphisms in the <i>IFIH1</i> results in fatal genetic disorders such as Aicardi–Goutières syndrome and Singleton...

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Bibliographic Details
Main Authors: Vijayakumar Gosu, Santanu Sasidharan, Prakash Saudagar, Hak-Kyo Lee, Donghyun Shin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
Aicardi–Goutières syndrome
Singleton–Merten syndrome
melanoma differentiation-associated protein 5
<i>IFIH1</i>
molecular dynamic simulation
Online Access:https://www.mdpi.com/2218-273X/11/8/1251

Internet

https://www.mdpi.com/2218-273X/11/8/1251

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