Modeling lung diseases using reversibly immortalized mouse pulmonary alveolar type 2 cells (imPAC2)

Modeling lung diseases using reversibly immortalized mouse pulmonary alveolar type 2 cells (imPAC2)

Abstract Background A healthy alveolar epithelium is critical to the gas exchange function of the lungs. As the major cell type of alveolar epithelium, alveolar type 2 (AT2) cells play a critical role in maintaining pulmonary homeostasis by serving as alveolar progenitors during lung injury, inflamm...

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Bibliographic Details
Main Authors: Linghuan Zhang, Wenping Luo, Jiang Liu, Maozhu Xu, Qi Peng, Wenjing Zou, Jingyi You, Yi Shu, Piao Zhao, William Wagstaff, Guozhi Zhao, Kevin Qin, Rex C. Haydon, Hue H. Luu, Russell R. Reid, Yang Bi, Tianyu Zhao, Tong-Chuan He, Zhou Fu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell & Bioscience
Subjects:
Alveolar type 2 cells (AT2)
Pulmonary alveolar epithelium
Immortalization
Alveolar organoids
Lung progenitors
Pulmonary fibrosis
Online Access:https://doi.org/10.1186/s13578-022-00894-4

Internet

https://doi.org/10.1186/s13578-022-00894-4

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