In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19

In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19

Ayurvedic medicines Withania somnifera Dunal (ashwagandha) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present study explores the effect of Ashwagandha and AYUSH-64 on important human CYP enzymes (CYP3A4, CYP2C8, and CYP2D6) to assess their interaction wit...

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Bibliographic Details
Main Authors: Siva Swapna Kasarla, Swapnil P. Borse, Yashwant Kumar, Neha Sharma, Madhu Dikshit
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
Withania somnifera
Ayurveda
remdesivir
integrative medicine
Rasayana
LC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.973768/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.973768/full

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