CSL362 potently and specifically depletes pDCs in vitro and ablates SLE-immune complex-induced IFN responses

CSL362 potently and specifically depletes pDCs in vitro and ablates SLE-immune complex-induced IFN responses

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with significant morbidity and mortality. Type I interferon (IFN) drives SLE pathology and plasmacytoid dendritic cells (pDCs) are potent producers of IFN; however, the specific effects of pDC depletion have not been demonstrated....

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Bibliographic Details
Main Authors: Katherine A. Monaghan, Alberta Hoi, Cristina Gamell, Tsin Yee Tai, Bryan Linggi, Jarrat Jordan, Matteo Cesaroni, Takahiro Sato, Milica Ng, Shereen Oon, Jacqueline Benson, Ian Wicks, Eric Morand, Nicholas Wilson
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Health sciences
Immunology
Pathophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012506

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223012506

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