Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease and obesity. THM1 (also termed TTC21B or IFT139) enc...

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Bibliographic Details
Main Authors: Damon T. Jacobs, Luciane M. Silva, Bailey A. Allard, Michael P. Schonfeld, Anindita Chatterjee, George C. Talbott, David R. Beier, Pamela V. Tran
Format: Article
Language:English
Published: The Company of Biologists 2016-07-01
Series:Disease Models & Mechanisms
Subjects:
Primary cilia
IFT complex A
POMC
Obesity mouse model
Online Access:http://dmm.biologists.org/content/9/7/789

Internet

http://dmm.biologists.org/content/9/7/789

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