An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase

An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase

The second step of eukaryotic lipid-linked oligosaccharide (LLO) biosynthesis is catalyzed by the conserved ALG13/ALG14 heterodimeric UDP-N-acetylglucosamine transferase (GnTase). In humans, mutations in ALG13 or ALG14 lead to severe neurological disorders with a multisystem phenotype, known as ALG1...

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Bibliographic Details
Main Authors: Chun-Di Wang, Si Xu, Shuai Chen, Zheng-Hui Chen, Neta Dean, Ning Wang, Xiao-Dong Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
N-glycosylation
lipid-linked oligosaccharide (LLO)
ALG glycosyltransferases
ALG13/14 UDP-N-acetylglucosamine transferase
ALG13 isoforms
congenital disorders of glycosylation (CDG)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1008078/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.1008078/full

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