The effect of denosumab on disseminated tumor cells (DTCs) of breast cancer patients with neoadjuvant treatment: a GeparX translational substudy

The effect of denosumab on disseminated tumor cells (DTCs) of breast cancer patients with neoadjuvant treatment: a GeparX translational substudy

Abstract Background Disseminated tumor cells (DTCs) in the bone marrow are observed in about 40% at primary diagnosis of breast cancer and predict poor survival. While anti-resorptive therapy with bisphosphonates was shown to eradicate minimal residue disease in the bone marrow, the effect of denosu...

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Bibliographic Details
Main Authors: Pauline Wimberger, Jens-Uwe Blohmer, Petra Krabisch, Theresa Link, Marianne Just, Bruno Valentin Sinn, Eike Simon, Christine Solbach, Tanja Fehm, Carsten Denkert, Cristin Kühn, Kerstin Rhiem, Hans Tesch, Sherko Kümmel, Andrea Petzold, Oliver Stötzer, Cornelia Meisel, Jan Dominik Kuhlmann, Valentina Nekljudova, Sibylle Loibl
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Breast Cancer Research
Subjects:
GeparX trial
Denosumab
Disseminated tumor cells
Bone marrow
Neoadjuvant chemotherapy
Online Access:https://doi.org/10.1186/s13058-023-01619-2

Internet

https://doi.org/10.1186/s13058-023-01619-2

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