TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein

TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein

The presence of proteinopathy, the accumulation of specific proteins as aggregates in neurons, is an emerging aspect of the pathology of schizophrenia and other major mental illnesses. Among the initial proteins implicated in forming such aggregates in these conditions is Trio and F-actin Binding Pr...

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Bibliographic Details
Main Authors: Beti Zaharija, Maja Odorčić, Anja Hart, Bobana Samardžija, Rita Marreiros, Ingrid Prikulis, Maja Juković, Thomas M. Hyde, Joel E. Kleinman, Carsten Korth, Nicholas J. Bradshaw
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
domain structure
major depressive disorder
protein aggregation
proteinopathy
schizophrenia
TRIOBP-1
Online Access:https://www.mdpi.com/1422-0067/23/19/11048

Internet

https://www.mdpi.com/1422-0067/23/19/11048

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