Genome-based prediction of cross-protective, HLA-DR-presented epitopes as putative vaccine antigens for multiple Bordetella species

Genome-based prediction of cross-protective, HLA-DR-presented epitopes as putative vaccine antigens for multiple Bordetella species

ABSTRACT Acellular pertussis vaccines protect against severe pertussis, but vaccine-induced immunity wanes over time. Prior animal studies showed that T-cell responses are integral to long-lasting immunity. Current pertussis vaccines also do not provide considerable protection against other species...

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Bibliographic Details
Main Authors: Muktha S. Natrajan, Jesse M. Hall, Michael R. Weigand, Yanhui Peng, Margaret M. Williams, Mohamed Momin, Frederick Heath Damron, Purnima Dubey, Maria Lucia Tondella, Lucia C. Pawloski
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
Bordetella pertussis
epitope vaccines
cross-protection
immunogenicity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03527-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03527-23

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