Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants

Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants

Abstract Background Preterm birth affects almost 9–11% of newborns and is one of the leading causes of childhood neurodevelopmental disabilities; the underlying molecular networks are poorly defined. In neurons, retrotransposons LINE-1 (L1) are an active source of genomic mosaicism that is deregulat...

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Bibliographic Details
Main Authors: Camilla Fontana, Federica Marasca, Livia Provitera, Sara Mancinelli, Nicola Pesenti, Shruti Sinha, Sofia Passera, Sergio Abrignani, Fabio Mosca, Simona Lodato, Beatrice Bodega, Monica Fumagalli
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Medicine
Subjects:
Prematurity
Early maternal care
LINE1 methylation
Neurodevelopment
Online Access:https://doi.org/10.1186/s12916-020-01896-0

Internet

https://doi.org/10.1186/s12916-020-01896-0

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