The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Abstract Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand extravasation kinetics and extravascular organ concentrations of AlbudAbs in huma...

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Bibliographic Details
Main Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland, Mats Bergstrom, Marie Davies
Format: Article
Language:English
Published: SpringerOpen 2019-05-01
Series:EJNMMI Research
Subjects:
Domain antibody
Albumin
AlbudAb
PET/CT
Biodistribution
89Zr
Online Access:http://link.springer.com/article/10.1186/s13550-019-0514-9

Internet

http://link.springer.com/article/10.1186/s13550-019-0514-9

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