Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression

Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression

We have previously described the LCGA-17 peptide as a novel anxiolytic and antidepressant candidate that acts through the α2δ VGCC (voltage-gated calcium channel) subunit with putative synergism with GABA-A receptors. The current study tested the potential efficacy of acute and chronic intranasal (i...

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Bibliographic Details
Main Authors: Anton V. Malyshev, Iuliia A. Sukhanova, Valeria M. Ushakova, Yana A. Zorkina, Olga V. Abramova, Anna Y. Morozova, Eugene A. Zubkov, Nikita A. Mitkin, Vsevolod V. Pavshintsev, Igor I. Doronin, Vasilina R. Gedzun, Gennady A. Babkin, Sergio A. Sanchez, Miah D. Baker, Colin N. Haile
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
chronic stress
novel treatment
peptide drug
biogenic amines
Online Access:https://www.mdpi.com/1424-8247/15/4/462

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https://www.mdpi.com/1424-8247/15/4/462

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