The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis

The proportion and phenotypic changes of CD4+CD25−Foxp3+ T cells in patients with untreated rheumatoid arthritis

Highlights The proportion of CD4+CD25−Foxp3+ T cells was elevated in untreated RA. CD4+CD25−Foxp3+ T cells expressed decreased Helios compared with Treg cells in both RA patients and HCs. CD4+CD25−Foxp3+ T cells produced increased IFN-γ compared with Tregs in RA patients. Elevated CD4+CD25−Foxp3+ T...

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Bibliographic Details
Main Authors: Bomiao Ju, Li Zhu, Jing Wang, Jian Zheng, Zhiming Hao, Jing Luo, Jing Zhang, Nan Hu, Qi An, Xiuyuan Feng, Yongwei Huo, Lan He
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Immunology
Subjects:
Rheumatoid arthritis
CD4+CD25−Foxp3+ T cells
CD4+CD25+Foxp3+ T cells
Disease activity
Phenotypic
Online Access:https://doi.org/10.1186/s12865-022-00517-0

Internet

https://doi.org/10.1186/s12865-022-00517-0

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