Efficient biosynthesis of (R)-mandelic acid from styrene oxide by an adaptive evolutionary Gluconobacter oxydans STA

Efficient biosynthesis of (R)-mandelic acid from styrene oxide by an adaptive evolutionary Gluconobacter oxydans STA

Abstract Background (R)-mandelic acid (R-MA) is a highly valuable hydroxyl acid in the pharmaceutical industry. However, biosynthesis of optically pure R-MA remains significant challenges, including the lack of suitable catalysts and high toxicity to host strains. Adaptive laboratory evolution (ALE)...

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Bibliographic Details
Main Authors: Fei Liu, Junping Zhou, Mengkai Hu, Yan Chen, Jin Han, Xuewei Pan, Jiajia You, Meijuan Xu, Taowei Yang, Minglong Shao, Xian Zhang, Zhiming Rao
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
(R)-mandelic acid
Gluconobacter oxydans
Adaptive laboratory evolution
Promoters
Styrene oxide
Biotransformation
Online Access:https://doi.org/10.1186/s13068-023-02258-7

Internet

https://doi.org/10.1186/s13068-023-02258-7

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