Carboxylic acid reductases enable intramolecular lactamization reactions

Carboxylic acid reductases enable intramolecular lactamization reactions

As a versatile type of enzyme, carboxylic acid reductases (CAR) can not only reduce various carboxylic acids to aldehydes in cooperation with cofactors ATP and NADPH but also catalyze the synthesis of amides and esters in the absence of NADPH. Here, we report an intramolecular cyclization catalyzed...

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Bibliographic Details
Main Authors: Zongmin Qin, Xiaohui Zhang, Xianke Sang, Wuyuan Zhang, Ge Qu, Zhoutong Sun
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-08-01
Series:Green Synthesis and Catalysis
Subjects:
Biocatalysis
Lactams
Carboxylic acid reductase
Intramolecular cyclization
Lactamization
Online Access:http://www.sciencedirect.com/science/article/pii/S2666554922000606

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http://www.sciencedirect.com/science/article/pii/S2666554922000606

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