The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly

The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly

Background/Aims: We recently discovered that harmful variants in THSD1 (Thrombospondin type-1 domain-containing protein 1) likely cause intracranial aneurysm and subarachnoid hemorrhage in a subset of both familial and sporadic patients with supporting evidence from two vertebrate models. The curren...

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Bibliographic Details
Main Authors: Yan-Ning Rui, Zhen Xu, Xiaoqian Fang, Miriam R. Menezes, Julien Balzeau, Airu Niu, John P. Hagan, Dong H. Kim
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Thsd1
Focal adhesion
Endosome
Protein complex
Online Access:https://www.karger.com/Article/FullText/484298

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https://www.karger.com/Article/FullText/484298

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