Role of Src and Cortactin in Pemphigus Skin Blistering

Role of Src and Cortactin in Pemphigus Skin Blistering

Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). Src was proposed to contribute to loss of keratinocyte cohesion. However, the role and underlying mechanisms are unclear and were studied here. In keratinocytes, ce...

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Bibliographic Details
Main Authors: Daniela Kugelmann, Vera Rötzer, Elias Walter, Desalegn Tadesse Egu, Michael Tobias Fuchs, Franziska Vielmuth, Hilda Vargas-Robles, Michael Schnoor, Michael Hertl, Rüdiger Eming, Klemens Rottner, Ansgar Schmidt, Volker Spindler, Jens Waschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
src
cortactin
adhesion
skin blistering diseases
pemphigus vulgaris (PV)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00626/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00626/full

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