Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

Abstract Background The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear. Methods Leveraging summary statistics of large-scale GWAS(s) conducted in European-ancestry populations on body mass i...

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Bibliographic Details
Main Authors: Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Medicine
Subjects:
Polycystic ovary syndrome
Obesity
Body mass index
Fat distribution
Genome-wide cross-trait analysis
Online Access:https://doi.org/10.1186/s12916-022-02238-y

Internet

https://doi.org/10.1186/s12916-022-02238-y

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