Synapses, predictions, and prediction errors: A neocortical computational study of MDD using the temporal memory algorithm of HTM

Synapses, predictions, and prediction errors: A neocortical computational study of MDD using the temporal memory algorithm of HTM

IntroductionSynapses and spines play a significant role in major depressive disorder (MDD) pathophysiology, recently highlighted by the rapid antidepressant effect of ketamine and psilocybin. According to the Bayesian brain and interoception perspectives, MDD is formalized as being stuck in affectiv...

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Bibliographic Details
Main Authors: Mohamed A. Sherif, Mostafa Z. Khalil, Rammohan Shukla, Joshua C. Brown, Linda L. Carpenter
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Psychiatry
Subjects:
MDD
predictions
prediction error
ketamine
psilocybin
hierarchical temporal memory (HTM)
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.976921/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2023.976921/full

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