A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

Abstract The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses. We previously established long-term expanding human lung epithelial organoids from lung tissues and developed a ‘proximal’ differentiat...

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Bibliographic Details
Main Authors: Man Chun Chiu, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Ding Xiao, Hin Chu, Jian-Piao Cai, Biao Zhou, Ko-Yung Sit, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Zhiwei Chen, Shibo Jiang, Hans Clevers, Kwok Yung Yuen, Jie Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00422-1

Internet

https://doi.org/10.1038/s41421-022-00422-1

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