Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells

Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells

Abstract Rat pheochromocytoma (PC12) cells were treated with the proteasome inhibitor MG-132 and morphological changes were recorded. Initially, neuronal differentiation was induced but after 24 h signs of morphological deterioration became apparent. We performed nuclear staining, flow cytometry and...

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Main Authors: Oktávia Tarjányi, Julian Haerer, Mónika Vecsernyés, Gergely Berta, Alexandra Stayer-Harci, Bálint Balogh, Kornélia Farkas, Ferenc Boldizsár, József Szeberényi, György Sétáló
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09763-z

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https://doi.org/10.1038/s41598-022-09763-z

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