Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.

Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.

Bacterial pathogens like Mycobacterium tuberculosis (Mtb) encounter acidic microenvironments in the host and must maintain their acid-base homeostasis to survive. A genetic screen identified two Mtb strains that cannot control intrabacterial pH (pHIB) in an acidic environment; infection with either...

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Bibliographic Details
Main Authors: Crystal M Darby, Helgi I Ingólfsson, Xiuju Jiang, Chun Shen, Mingna Sun, Nan Zhao, Kristin Burns, Gang Liu, Sabine Ehrt, J David Warren, Olaf S Andersen, Steven J Brickner, Carl Nathan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728290?pdf=render

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http://europepmc.org/articles/PMC3728290?pdf=render

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