The magnitude of the germinal center B cell and T follicular helper cell response predicts long-lasting antibody titers to plague vaccination

The magnitude of the germinal center B cell and T follicular helper cell response predicts long-lasting antibody titers to plague vaccination

The development of a safe and effective vaccine against Yersinia pestis, the causative organism for plague disease, remains an important global health priority. Studies have demonstrated effective immune-based protection against plague challenge that is induced by plague antigen subunit vaccination...

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Bibliographic Details
Main Authors: Darrell R. Galloway, Nguyen X. Nguyen, Jiahui Li, Nicholas Houston, Gage Gregersen, E. Diane Williamson, Frank W. Falkenberg, James N. Herron, J. Scott Hale
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
T follicular helper cell
germinal center
B cell response
antibodies
Yersinia pestis (plague)
vaccination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017385/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017385/full

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