Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In the current study, we sought to investigate the prognostic value of TLS-associated chemokines/cytokines (TLS-kines) expression levels in...

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Bibliographic Details
Main Authors: Lilit Karapetyan, Hassan M. AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P. MacFawn, Zachary J. Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R. Kunning, Yana G. Najjar, Diwakar Davar, Jason J. Luke, William Gooding, Tullia C. Bruno, John M. Kirkwood, Walter J. Storkus
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
tertiary lymphoid structure
lymphoid aggregate
melanoma
APRIL
TNFSF13
cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171978/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171978/full

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