CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis

CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis

The immunopathogenesis of multiple sclerosis (MS) depend on the expansion of specific inflammatory T cell subsets, which are key effectors of tissue damage and demyelination. Emerging studies evidence that a reprogramming of T cell metabolism may occur in MS, thus the identification of stimulatory m...

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Bibliographic Details
Main Authors: Martina Kunkl, Manolo Sambucci, Serena Ruggieri, Carola Amormino, Carla Tortorella, Claudio Gasperini, Luca Battistini, Loretta Tuosto
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
multiple sclerosis
inflammation
Th17 cells
glycolysis
CD28
c-myc
class 1A PI3K
Online Access:https://www.mdpi.com/2073-4409/8/6/575

Internet

https://www.mdpi.com/2073-4409/8/6/575

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