Drug binding and drug-drug interaction considerations in individuals with obesity before and after bariatric surgery: A retrospective cross-sectional study

Drug binding and drug-drug interaction considerations in individuals with obesity before and after bariatric surgery: A retrospective cross-sectional study

Obesity impacts pharmacokinetic and pharmacodynamic parameters, changing the drug-binding state via plasma proteins, which is critical for drug effectiveness and toxicity. Albumin and α1-acid glycoprotein (AAG) are the two main proteins accountable for drug binding in humans. Previous studies have s...

Full description

Bibliographic Details
Main Authors: Emerita Quintina de Andrade Moura, Carolina Dumke de Siqueira, Ana Carolina Martins, Bruno Fonseca Nunes, Ana Carolina Rabello de Moraes, Fabíola Branco Filippin-Monteiro
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Medicine in Drug Discovery
Subjects:
α-1 acid glycoprotein
Obesity
Bariatric surgery
Protein binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098623000027

Internet

http://www.sciencedirect.com/science/article/pii/S2590098623000027

Similar Items