Reducing the Excess Activin Signaling Rescues Muscle Degeneration in Myotonic Dystrophy Type 2 <i>Drosophila</i> Model

Reducing the Excess Activin Signaling Rescues Muscle Degeneration in Myotonic Dystrophy Type 2 <i>Drosophila</i> Model

Expanded non-coding RNA repeats of CCUG are the underlying genetic causes for myotonic dystrophy type 2 (DM2). There is an urgent need for effective medications and potential drug targets that may alleviate the progression of the disease. In this study, 3140 small-molecule drugs from FDA-approved li...

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Bibliographic Details
Main Authors: Jing Deng, Xin-Xin Guan, Ying-Bao Zhu, Hai-Tao Deng, Guang-Xu Li, Yi-Chen Guo, Peng Jin, Ran-Hui Duan, Wen Huang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Personalized Medicine
Subjects:
chemical screen
<i>Drosophila</i>
myotonic dystrophy type 2
TGF-β pathway
Online Access:https://www.mdpi.com/2075-4426/12/3/385

Internet

https://www.mdpi.com/2075-4426/12/3/385

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