pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

Abstract Background Multidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P-gp) that reduce the intracellular accumulation of various chemotherape...

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Bibliographic Details
Main Authors: Sipei Zhang, Nan Guo, Guoyun Wan, Tao Zhang, Chunyu Li, Yongfei Wang, Yinsong Wang, Yuanyuan Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Nanobiotechnology
Subjects:
pH and redox dual-responsive
Nanoparticle
Celecoxib
Drug resistance
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12951-019-0540-9

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http://link.springer.com/article/10.1186/s12951-019-0540-9

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