EB1089 Increases the Antiproliferative Response of Lapatinib in Combination with Antiestrogens in HER2-Positive Breast Cancer Cells

EB1089 Increases the Antiproliferative Response of Lapatinib in Combination with Antiestrogens in HER2-Positive Breast Cancer Cells

HER2-positive breast cancer is associated with aggressive behavior and reduced survival rates. Calcitriol restores the antiproliferative activity of antiestrogens in estrogen receptor (ER)-negative breast cancer cells by re-expressing ERα. Furthermore, calcitriol and its analog, EB1089, enhance resp...

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Bibliographic Details
Main Authors: Angèle Sorel Achounna, David Ordaz-Rosado, Janice García-Quiroz, Gabriela Morales-Guadarrama, Edgar Milo-Rocha, Fernando Larrea, Lorenza Díaz, Rocío García-Becerra
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
HER2-positive breast cancer
EB1089
lapatinib
tamoxifen
fulvestrant
Online Access:https://www.mdpi.com/1422-0067/25/6/3165

Internet

https://www.mdpi.com/1422-0067/25/6/3165

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