Recombinant Extracellular Domain (p75ECD) of the Neurotrophin Receptor p75 Attenuates Myocardial Ischemia–Reperfusion Injury by Inhibiting the p‐JNK/Caspase‐3 Signaling Pathway in Rat Microvascular Pericytes

Recombinant Extracellular Domain (p75ECD) of the Neurotrophin Receptor p75 Attenuates Myocardial Ischemia–Reperfusion Injury by Inhibiting the p‐JNK/Caspase‐3 Signaling Pathway in Rat Microvascular Pericytes

Background Pro‐NTs (precursor of neurotrophins) and their receptor p75 are potential targets for preventing microvascular dysfunction induced by myocardial ischemia–reperfusion injury (IRI). p75ECD (ectodomain of neurotrophin receptor p75) may physiologically produce neurocytoprotective effects by s...

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Bibliographic Details
Main Authors: Jun Fang, ZhiXiong Wei, DeDong Zheng, Teng Ying, HuaShan Hong, DanQing Hu, YunLing Lin, XiaoLiang Jiang, LingZhen Wu, TingXiang Lan, ZhiWei Yang, XinFu Zhou, LiangLong Chen
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
c‐Jun N‐terminal kinase
extracellular domain
microvascular dysfunction
neurotrophin receptor
pericyte
reperfusion injury
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.016047

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https://www.ahajournals.org/doi/10.1161/JAHA.119.016047

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