Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication

Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication

AbstractHepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA helicase, and RNA-dependent RNA polymerase (RdRp). U...

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Bibliographic Details
Main Authors: Akash Kumar, Preeti Hooda, Anindita Puri, Radhika Khatter, Mohammed S. Al-Dosari, Neha Sinha, Mohammad K. Parvez, Deepak Sehgal
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Hepatitis E virus
helicase
RNA replication
antiviral
methotrexate
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2280500

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2280500

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