Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic acti...
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Format: | Article |
Language: | English |
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Bogor Agricultural University
2019-10-01
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Series: | Hayati Journal of Biosciences |
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Online Access: | https://journal.ipb.ac.id/index.php/hayati/article/view/27984 |
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author | Tati Herlina Nayla Haraswati Riza Apriani Vicki Nishinarizki Shabarni Gaffar Unang Supratman |
author_facet | Tati Herlina Nayla Haraswati Riza Apriani Vicki Nishinarizki Shabarni Gaffar Unang Supratman |
author_sort | Tati Herlina |
collection | DOAJ |
description | Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell. |
first_indexed | 2024-12-19T17:29:41Z |
format | Article |
id | doaj.art-ebbe70aa670049b5b1e3e7c6f334f7f9 |
institution | Directory Open Access Journal |
issn | 1978-3019 2086-4094 |
language | English |
last_indexed | 2024-12-19T17:29:41Z |
publishDate | 2019-10-01 |
publisher | Bogor Agricultural University |
record_format | Article |
series | Hayati Journal of Biosciences |
spelling | doaj.art-ebbe70aa670049b5b1e3e7c6f334f7f92022-12-21T20:12:29ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192086-40942019-10-0126210.4308/hjb.26.2.%xCytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) CellsTati Herlina0Nayla Haraswati1Riza Apriani2Vicki Nishinarizki3Shabarni Gaffar4Unang Supratman5Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangCancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell.https://journal.ipb.ac.id/index.php/hayati/article/view/27984Erythrina poeppigianaalpinumisoflavonecytotoxic activity |
spellingShingle | Tati Herlina Nayla Haraswati Riza Apriani Vicki Nishinarizki Shabarni Gaffar Unang Supratman Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells Hayati Journal of Biosciences Erythrina poeppigiana alpinumisoflavone cytotoxic activity |
title | Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells |
title_full | Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells |
title_fullStr | Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells |
title_full_unstemmed | Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells |
title_short | Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells |
title_sort | cytotoxic activity of alpinumisoflavone from erythrina poeppigiana leguminosae against colon cancer widr cervical cancer hela and hepatoma cancer hepg2 cells |
topic | Erythrina poeppigiana alpinumisoflavone cytotoxic activity |
url | https://journal.ipb.ac.id/index.php/hayati/article/view/27984 |
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