Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells

Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic acti...

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Main Authors: Tati Herlina, Nayla Haraswati, Riza Apriani, Vicki Nishinarizki, Shabarni Gaffar, Unang Supratman
Format: Article
Language:English
Published: Bogor Agricultural University 2019-10-01
Series:Hayati Journal of Biosciences
Subjects:
Online Access:https://journal.ipb.ac.id/index.php/hayati/article/view/27984
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author Tati Herlina
Nayla Haraswati
Riza Apriani
Vicki Nishinarizki
Shabarni Gaffar
Unang Supratman
author_facet Tati Herlina
Nayla Haraswati
Riza Apriani
Vicki Nishinarizki
Shabarni Gaffar
Unang Supratman
author_sort Tati Herlina
collection DOAJ
description Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell.
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spelling doaj.art-ebbe70aa670049b5b1e3e7c6f334f7f92022-12-21T20:12:29ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192086-40942019-10-0126210.4308/hjb.26.2.%xCytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) CellsTati Herlina0Nayla Haraswati1Riza Apriani2Vicki Nishinarizki3Shabarni Gaffar4Unang Supratman5Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, SumedangCancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoflavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoflavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoflavone has antiproliferative effect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoflavone is very cytotoxic to colon cancer WiDr cell.https://journal.ipb.ac.id/index.php/hayati/article/view/27984Erythrina poeppigianaalpinumisoflavonecytotoxic activity
spellingShingle Tati Herlina
Nayla Haraswati
Riza Apriani
Vicki Nishinarizki
Shabarni Gaffar
Unang Supratman
Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
Hayati Journal of Biosciences
Erythrina poeppigiana
alpinumisoflavone
cytotoxic activity
title Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
title_full Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
title_fullStr Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
title_full_unstemmed Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
title_short Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells
title_sort cytotoxic activity of alpinumisoflavone from erythrina poeppigiana leguminosae against colon cancer widr cervical cancer hela and hepatoma cancer hepg2 cells
topic Erythrina poeppigiana
alpinumisoflavone
cytotoxic activity
url https://journal.ipb.ac.id/index.php/hayati/article/view/27984
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