USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity

USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity

Oncogene-induced senescence (OIS) occurs in premalignant lung adenomas, but infrequently in malignant adenocarcinomas. Here the authors show that USP5-Beclin 1 axis overcomes OIS in Kras-driven lung cancer by enhancing MDM2-mediated p53 degradation.

Bibliographic Details
Main Authors: Juan Li, Yang Wang, Yue Luo, Yang Liu, Yong Yi, Jinsong Li, Yang Pan, Weiyuxin Li, Wanbang You, Qingyong Hu, Zhiqiang Zhao, Yujun Zhang, Yang Cao, Lingqiang Zhang, Junying Yuan, Zhi-Xiong Jim Xiao
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35557-y

Internet

https://doi.org/10.1038/s41467-022-35557-y

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