Stable Expression of a Hepatitis E Virus (HEV) RNA Replicon in Two Mammalian Cell Lines to Assess Mechanism of Innate Immunity and Antiviral Response

Stable Expression of a Hepatitis E Virus (HEV) RNA Replicon in Two Mammalian Cell Lines to Assess Mechanism of Innate Immunity and Antiviral Response

Hepatitis E virus (HEV) is one of the major etiological agents responsible for acute hepatitis. Hepatitis E virus does not replicate efficiently in mammalian cell cultures, thus a useful model that mimics persistent HEV replication is needed to dissect the molecular mechanism of pathogenesis. Here w...

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Bibliographic Details
Main Authors: Ling-Dong Xu, Fei Zhang, Lei Peng, Wen-Ting Luo, Chu Chen, Pinglong Xu, Yao-Wei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Microbiology
Subjects:
hepatitis E virus (HEV)
replicon
antiviral drugs
interferon
innate immune sensing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.603699/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.603699/full

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