Metyrapone, an inhibitor of cytochrome oxidases, does not affect viability in a neuroblastoma cell model of bilirubin toxicity

Metyrapone, an inhibitor of cytochrome oxidases, does not affect viability in a neuroblastoma cell model of bilirubin toxicity

Background: Unconjugated hyperbilirubinemia may cause brain damage in infants, and globally remains a source of neonatal morbidity and mortality. A significant inter-individual variability in vulnerability to bilirubin toxicity remains largely unexplained. An enzyme located in mitochondria oxidizes...

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Bibliographic Details
Main Authors: Maria N. Naguib Leerberg, Tomas N. Alme, Thor W.R. Hansen
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Bilirubin
Neurotoxicity
Cell culture
Kernicterus
Cytochrome P450 oxidase
Metyrapone
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426914000305

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http://www.sciencedirect.com/science/article/pii/S2214426914000305

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