The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen

Kv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is poorly understood. Here we show that Kv1.3-de...

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Bibliographic Details
Main Authors: Joy R Wright, Sarah Jones, Sasikumar Parvathy, Leonard K Kaczmarek, Ian Forsythe, Richard W Farndale, Jonathan M Gibbins, Martyn P Mahaut-Smith
Format: Article
Language:English
Published: Taylor & Francis Group 2022-04-01
Series:Platelets
Online Access:http://dx.doi.org/10.1080/09537104.2021.1942818