PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection

PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection

Abstract Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional structures than benign variants. Motivated by this tendency, we develop a fast and powerful protein-structure-based scan (PSCAN) approach for evaluating gene-level associations with complex dis...

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Bibliographic Details
Main Authors: Zheng-Zheng Tang, Gregory R. Sliwoski, Guanhua Chen, Bowen Jin, William S. Bush, Bingshan Li, John A. Capra
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Genome Biology
Subjects:
Gene-level association tests
Protein 3D structures
Spatial scan approach
Risk variant detection
Online Access:http://link.springer.com/article/10.1186/s13059-020-02121-0

Internet

http://link.springer.com/article/10.1186/s13059-020-02121-0

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