Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth

Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth

Glioblastoma, an invasive high-grade brain cancer, exhibits numerous treatment challenges. Amongst the current therapies, targeting functional receptors and active signaling pathways were found to be a potential approach for treating GBM. We exploited the role of endogenous expression of GPR17, a G...

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Bibliographic Details
Main Authors: Phuong Doan, Phung Nguyen, Akshaya Murugesan, Kumar Subramanian, Saravanan Konda Mani, Vignesh Kalimuthu, Bobin George Abraham, Brett W. Stringer, Kadalmani Balamuthu, Olli Yli-Harja, Meenakshisundaram Kandhavelu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
glioblastoma
GPR17-targeted drug
mode of action
cell death
toxicity
blood–brain barrier
Online Access:https://www.mdpi.com/2072-6694/13/15/3773

Internet

https://www.mdpi.com/2072-6694/13/15/3773

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