[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

The development of new classes of isosteres and building blocks is crucial to the advancement of medicinal chemistry programs. Here, the authors report the synthesis and development of ladderanes to act as replacements for meta-substituted aromatic rings and cyclohexanes.

Bibliographic Details
Main Authors: Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33827-3

Internet

https://doi.org/10.1038/s41467-022-33827-3

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