Exploring Candesartan, an angiotensin II receptor antagonist, as a novel inhibitor of NLRP3 inflammasome: alleviating inflammation in Neisseria gonorrhoeae infection

Exploring Candesartan, an angiotensin II receptor antagonist, as a novel inhibitor of NLRP3 inflammasome: alleviating inflammation in Neisseria gonorrhoeae infection

Abstract Background Gonorrhea, induced by Neisseria gonorrhoeae infection, stands as a prevalent sexually transmitted inflammatory disease globally. Our earlier research illuminated that N. gonorrhoeae-infected macrophages provoke inflammation by activating the intracellular sensor NACHT, LRR, and P...

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Bibliographic Details
Main Authors: Wen-Yu Lin, Jin-Lian Tsui, Hsiao-Wen Chiu, Wei-Ting Wong, Chun‑Hsien Wu, Hsien-Ta Hsu, Chen-Lung Ho, Shan-Pei Yeh, Yerra Koteswara Rao, Ann Chen, Chien-Chun Wang, Chung-Hua Hsu, Oleg V. Chernikov, Kuo-Feng Hua, Lan-Hui Li
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Infectious Diseases
Subjects:
Angiotensin II receptor antagonist
Candesartan
NLRP3 inflammasome
Neisseria gonorrhoeae
Online Access:https://doi.org/10.1186/s12879-024-10208-3

Internet

https://doi.org/10.1186/s12879-024-10208-3

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