Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

Upregulated miRNAs on the TP53 and RB1 Binding Seedless Regions in High-Risk HPV-Associated Penile Cancer

Cancer development by the human papillomavirus (HPV) infection can occur through the canonical HPV/p53/RB1 pathway mediated by the E2/E6/E7 viral oncoproteins. During the transformation process, HPV inserts its genetic material into host Integration Sites (IS), affecting coding genes and miRNAs. In...

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Bibliographic Details
Main Authors: Jenilson da Silva, Carla Cutrim da Costa, Ingryd de Farias Ramos, Ana Carolina Laus, Luciane Sussuchi, Rui Manuel Reis, André Salim Khayat, Luciane Regina Cavalli, Silma Regina Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Genetics
Subjects:
penile cancer
tumor suppressor repression
miRNA
HPV
TP53
Rb1
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.875939/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.875939/full

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