Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration

Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration

Abstract Exogenous stem cell therapy and endogenous repair has shown great potential in intervertebral disc regeneration. However, limited nutrients and accumulation of lactate largely impair the survival and regenerative capacity of implanted stem cells and endogenous nucleus pulposus cells (NPCs)....

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Bibliographic Details
Main Authors: Yizhong Peng, Xuanzuo Chen, Qimin Zhang, Sheng Liu, Wei Wu, Kanglu Li, Hui Lin, Xiangcheng Qing, Yan Xiao, BaiChuan Wang, Daping Quan, Shiqing Feng, Zilong Rao, Ying Bai, Zengwu Shao
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
autophagy
intervertebral disc degeneration
lactate
microfluidic system
nanozyme
TGFB2‐OT1
Online Access:https://doi.org/10.1002/advs.202304761

Internet

https://doi.org/10.1002/advs.202304761

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