Estimation of SARS-CoV-2 Neutralizing Activity and Protective Immunity in Different Vaccine Types Using Three Surrogate Virus Neutralization Test Assays and Two Semiquantitative Binding Assays Targeting the Receptor-Binding Domain

Estimation of SARS-CoV-2 Neutralizing Activity and Protective Immunity in Different Vaccine Types Using Three Surrogate Virus Neutralization Test Assays and Two Semiquantitative Binding Assays Targeting the Receptor-Binding Domain

ABSTRACT Estimating neutralizing activity in vaccinees is crucial for predicting the protective effect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the plaque reduction neutralization test (PRNT) requires a biosafety level 3 facility, it would be advantageous if surrogate...

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Bibliographic Details
Main Authors: Beomki Lee, Jae-Hoon Ko, Kyoung Hwa Lee, Yong Chan Kim, Young Goo Song, Yoon Soo Park, Yae Jee Baek, Jin Young Ahn, Jun Yong Choi, Kyoung-Ho Song, Eu Suk Kim, Seongman Bae, Sung-Han Kim, Hye Won Jeong, Shin-Woo Kim, Ki Tae Kwon, Su-Hwan Kim, Hyeonji Jeong, Byoungguk Kim, Sung Soon Kim, Won Suk Choi, Kyong Ran Peck, Eun-Suk Kang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
COVID-19
neutralization tests
sVNT
ChAdOx1
BNT162b2
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02669-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02669-22

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