Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew)

Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew)

Ghrelin has well-known activity to stimulate appetite and weight gain. Evidence suggests that ghrelin may also have effects in reducing chemotherapy-induced emesis via growth hormone secretagogue receptors (GHS-R1A) in the brain. However, it is not known whether the stimulation of GHS-R1A has broad...

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Bibliographic Details
Main Authors: John A. Rudd, Sze W. Chan, Man P. Ngan, Longlong Tu, Zengbing Lu, Claudio Giuliano, Emanuela Lovati, Claudio Pietra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
ghrelin
HM01
nausea
emesis
chemotherapy
motion
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00869/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00869/full

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