In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia

In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia

Structural fetal diseases, such as congenital diaphragmatic hernia (CDH) can be diagnosed prenatally. Neonates with CDH are healthy in utero as gas exchange is managed by the placenta, but impaired lung function results in critical illness from the time a baby takes its first breath. MicroRNA (miR)...

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Bibliographic Details
Main Authors: Sarah J. Ullrich, Nicholas K. Yung, Tory J. Bauer-Pisani, Nathan L. Maassel, Mary Elizabeth Guerra, Mollie Freedman-Weiss, Samantha L. Ahle, Adele S. Ricciardi, Maor Sauler, W. Mark Saltzman, Alexandra S. Piotrowski-Daspit, David H. Stitelman
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
particle-based fetal therapy
congenital diaphragmatic hernia
lung development
epigenetic therapy
microRNA therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312300104X

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http://www.sciencedirect.com/science/article/pii/S216225312300104X

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